Kun-Hsing Yu, MD, PhD

Kun-Hsing Yu, MD, PhD

Assistant Professor of Biomedical Informatics, Harvard Medical School
Assistant Professor of Pathology, Brigham and Women's Hospital
Instructor in Epidemiology, Harvard T.H. Chan School of Public Health
Yu Lab

Kun-Hsing "Kun" Yu received his PhD in Biomedical Informatics and PhD Minor in Computer Science from Stanford University, and he obtained his MD from National Taiwan University, Taiwan. His research focuses on the integration of quantitative histopathology image patterns with multi-omics (genomics, epigenomics, transcriptomics, and proteomics) profiles to advance cancer research and clinical practice. His team has developed fully-automated algorithms to analyze whole-slide histopathology images at scale, discovered the molecular mechanisms underpinning the microscopic phenotypes of tumor cells, and identified novel cellular morphologies for patient prognosis. His research interests include quantitative pathology, machine learning, and translational bioinformatics.

DBMI Research Areas
DBMI Courses
Current Postdoctoral Fellowship Opportunities
A survival guide for interdisciplinary PhD students.
Authors: Yu KH.
Nat Biotechnol
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Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.
Authors: Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC.
Cell Stem Cell
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Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features.
Authors: Yu KH, Zhang C, Berry GJ, Altman RB, Ré C, Rubin DL, Snyder M.
Nat Commun
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Predicting Ovarian Cancer Patients' Clinical Response to Platinum-Based Chemotherapy by Their Tumor Proteomic Signatures.
Authors: Yu KH, Levine DA, Zhang H, Chan DW, Zhang Z, Snyder M.
J Proteome Res
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Omics Profiling in Precision Oncology.
Authors: Yu KH, Snyder M.
Mol Cell Proteomics
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Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.
Authors: Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IM, Cope L, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD.
Cell
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The genetic predisposition to bronchopulmonary dysplasia.
Authors: Yu KH, Li J, Snyder M, Shaw GM, O'Brodovich HM.
Curr Opin Pediatr
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Exome Sequencing of Neonatal Blood Spots and the Identification of Genes Implicated in Bronchopulmonary Dysplasia.
Authors: Li J, Yu KH, Oehlert J, Jeliffe-Pawlowski LL, Gould JB, Stevenson DK, Snyder M, Shaw GM, O'Brodovich HM.
Am J Respir Crit Care Med
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A tale of two cities: understanding the differences in medical professionalism between two Chinese cultural contexts.
Authors: Ho MJ, Yu KH, Pan H, Norris JL, Liang YS, Li JN, Hirsh D.
Acad Med
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Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas.
Authors: Chiang SC, Han CL, Yu KH, Chen YJ, Wu KP.
PLoS One
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