Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Sunyaev Lab

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Triplet repeat length bias and variation in the human transcriptome.
Authors: Molla M, Delcher A, Sunyaev S, Cantor C, Kasif S.
Proc Natl Acad Sci U S A
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Multiplex padlock targeted sequencing reveals human hypermutable CpG variations.
Authors: Li JB, Gao Y, Aach J, Zhang K, Kryukov GV, Xie B, Ahlford A, Yoon JK, Rosenbaum AM, Zaranek AW, LeProust E, Sunyaev SR, Church GM.
Genome Res
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Human mutation rate associated with DNA replication timing.
Authors: Stamatoyannopoulos JA, Adzhubei I, Thurman RE, Kryukov GV, Mirkin SM, Sunyaev SR.
Nat Genet
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Power of deep, all-exon resequencing for discovery of human trait genes.
Authors: Kryukov GV, Shpunt A, Stamatoyannopoulos JA, Sunyaev SR.
Proc Natl Acad Sci U S A
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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML).
Authors: Sunyaev SR, Lugovskoy A, Simon K, Gorelik L.
PLoS Genet
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SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs.
Authors: Beckstead WA, Bjork BC, Stottmann RW, Sunyaev S, Beier DR.
Mamm Genome
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Erratum.
Authors: Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Kondrashov AS, Sunyaev S.
PLoS Genet
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Hypermutable non-synonymous sites are under stronger negative selection.
Authors: Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Adzuhbei IA, Kondrashov AS, Sunyaev S.
PLoS Genet
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Protein identification pipeline for the homology-driven proteomics.
Authors: Junqueira M, Spirin V, Balbuena TS, Thomas H, Adzhubei I, Sunyaev S, Shevchenko A.
J Proteomics
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Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification.
Authors: Junqueira M, Spirin V, Santana Balbuena T, Waridel P, Surendranath V, Kryukov G, Adzhubei I, Thomas H, Sunyaev S, Shevchenko A.
J Proteome Res
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