Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Sunyaev Lab

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Dobzhansky-Muller incompatibilities in protein evolution.
Authors: Kondrashov AS, Sunyaev S, Kondrashov FA.
Proc Natl Acad Sci U S A
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Human non-synonymous SNPs: server and survey.
Authors: Ramensky V, Bork P, Sunyaev S.
Nucleic Acids Res
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Charting the proteomes of organisms with unsequenced genomes by MALDI-quadrupole time-of-flight mass spectrometry and BLAST homology searching.
Authors: Shevchenko A, Sunyaev S, Loboda A, Shevchenko A, Bork P, Ens W, Standing KG.
Anal Chem
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Prediction of deleterious human alleles.
Authors: Sunyaev S, Ramensky V, Koch I, Lathe W, Kondrashov AS, Bork P.
Hum Mol Genet
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Integration of genome data and protein structures: prediction of protein folds, protein interactions and "molecular phenotypes" of single nucleotide polymorphisms.
Authors: Sunyaev S, Lathe W, Bork P.
Curr Opin Struct Biol
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SNP frequencies in human genes an excess of rare alleles and differing modes of selection.
Authors: Sunyaev SR, Lathe WC, Ramensky VE, Bork P.
Trends Genet
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Towards a structural basis of human non-synonymous single nucleotide polymorphisms.
Authors: Sunyaev S, Ramensky V, Bork P.
Trends Genet
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Individual variation in protein-coding sequences of human genome.
Authors: Sunyaev S, Hanke J, Brett D, Aydin A, Zastrow I, Lathe W, Bork P, Reich J.
Adv Protein Chem
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Prediction of nonsynonymous single nucleotide polymorphisms in human disease-associated genes.
Authors: Sunyaev S, Hanke J, Aydin A, Wirkner U, Zastrow I, Reich J, Bork P.
J Mol Med (Berl)
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PSIC: profile extraction from sequence alignments with position-specific counts of independent observations.
Authors: Sunyaev SR, Eisenhaber F, Rodchenkov IV, Eisenhaber B, Tumanyan VG, Kuznetsov EN.
Protein Eng
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