Shawn Norman Murphy, M.D., Ph.D.

Shawn Murphy, MD, PhD

Professor of Neurology at MGH
Associate Professor of Biomedical Informatics, Harvard Medical School (Secondary)

6177247980

Shawn Murphy currently serves as the Director of Research Computing and Informatics at Partners Healthcare and Associate Director for the Laboratory of Computer Science at the Massachusetts General Hospital where he developed the Research Patient Data Registry (RPDR) for Partners Healthcare. This application, which serves over 5,000 investigators performing research using the hospital medical record, served as the test bed for his work with Zak Kohane in developing the open source Informatics for Integrating Biology and the Bedside (i2b2) software platform now operating at over 120 hospitals worldwide. Murphy’s contribution as chief architect of the i2b2 platform has served to strengthen the understanding of the metabolic and genetic underpinnings of complex diseases by developing an informatics framework to integrate data for clinical research from electronic health records.

Achieving automated narrative text interpretation using phrases in the electronic medical record.
Authors: Murphy SN, Barnett GO.
Proc AMIA Annu Fall Symp
View full abstract on Pubmed
Nitrendipine and omega-conotoxin modulate gonadotropin release and gonadotrope [Ca2+]i.
Authors: Blotner M, Shangold GA, Lee EY, Murphy SN, Miller RJ.
Mol Cell Endocrinol
View full abstract on Pubmed
Two distinct quisqualate receptors regulate Ca2+ homeostasis in hippocampal neurons in vitro.
Authors: Murphy SN, Miller RJ.
Mol Pharmacol
View full abstract on Pubmed
Regulation of Ca++ influx into striatal neurons by kainic acid.
Authors: Murphy SN, Miller RJ.
J Pharmacol Exp Ther
View full abstract on Pubmed
A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.
Authors: Murphy SN, Miller RJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Gonadotropin-releasing hormone-induced Ca2+ transients in single identified gonadotropes require both intracellular Ca2+ mobilization and Ca2+ influx.
Authors: Shangold GA, Murphy SN, Miller RJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro.
Authors: Murphy SN, Thayer SA, Miller RJ.
J Neurosci
View full abstract on Pubmed
3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine.
Authors: Reynolds IJ, Murphy SN, Miller RJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Widespread distribution of dihydropyridine-sensitive calcium channels in the central nervous system.
Authors: Thayer SA, Murphy SN, Miller RJ.
Mol Pharmacol
View full abstract on Pubmed