Arjun Manrai

Arjun (Raj) Manrai, PhD

Assistant Professor of Biomedical Informatics, Harvard Medical School
Deputy Editor, NEJM AI

10 Shattuck Street #304, Boston, MA, 02115

Arjun (Raj) Manrai, PhD is an Assistant Professor in the Department of Biomedical Informatics at Harvard Medical School, where he leads a research lab that works broadly on applying machine learning and statistical modeling to improve medical decision-making. Raj is also a founding Deputy Editor of NEJM AI, the new artificial intelligence-focused journal from the publishers of the New England Journal of Medicine, and co-host of the NEJM AI Grand Rounds podcast.

Focus areas for Raj’s research group include the role of artificial intelligence in medical diagnosis, the clinical use of genomic data and blood laboratory biomarkers, inherited heart disease and kidney disease, decision making across populations, and reproducibility and safety challenges for medical artificial intelligence. His work has been published in the New England Journal of Medicine and JAMA, presented at the National Academy of Sciences, and featured in the New York Times, Wall Street Journal, and NPR.

Raj is also closely involved in the mentoring of students at Harvard College, having served for over a decade as a Resident Tutor and now member of the Senior Common Room of Leverett House. Students from the lab have won the Rhodes, PD Soros, and other awards to continue their training and research in machine learning and medicine.

Raj earned an AB in Physics from Harvard College followed by a PhD in Bioinformatics and Integrative Genomics from the Harvard-MIT Division of Health Sciences and Technology (HST).

He resides in the Boston area and outside work he can usually be found losing home dance competitions to his 2 young daughters.

DBMI Research Areas
DBMI Courses
Development of exposome correlation globes to map out environment-wide associations.
Authors: Patel CJ, Manrai AK.
Pac Symp Biocomput
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Medicine's uncomfortable relationship with math: calculating positive predictive value.
Authors: Manrai AK, Bhatia G, Strymish J, Kohane IS, Jain SH.
JAMA Intern Med
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Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
Authors: Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Yarmush J, Jiao Y, Fletcher A, Lee J, Cima MJ, Yarmush ML, Parekkadan B.
Mol Ther
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Urinary-cell mRNA and acute kidney-transplant rejection.
Authors: Manrai AK, Kohane IS, Szolovits P.
N Engl J Med
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CEAS: cis-regulatory element annotation system.
Authors: Shin H, Liu T, Manrai AK, Liu XS.
Bioinformatics
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Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.
Authors: Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M.
Cell
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The geometry of multisite phosphorylation.
Authors: Manrai AK, Gunawardena J.
Biophys J
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Model-based analysis of two-color arrays (MA2C).
Authors: Song JS, Johnson WE, Zhu X, Zhang X, Li W, Manrai AK, Liu JS, Chen R, Liu XS.
Genome Biol
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