Doga Gulhan, PhD
Assistant Professor of Medicine, Massachusetts General Hospital
Assistant Professor of Biomedical Informatics, Harvard Medical School (Secondary)
Doga Gulhan is the Principal Investigator of Gulhan Lab at Mass General Hospital (MGH) Cancer Center and a Faculty Member HMS. She received her Bachelor of Science degree from Bilkent University's Physics Department. She completed her Ph.D. in high-energy physics at the Massachusetts Institute of Technology and worked as a Research Fellow at CERN. After transitioning to biomedical informatics, she joined Park Lab at the Department of Biomedical Informatics at HMS as a postdoctoral fellow. She studied mutational processes in cancer using signature analysis techniques. She contributed new algorithms to this emerging field that expanded its clinical applications by enabling signature prediction from targeted gene panels (Gulhan et al Nat Genet. 2019) and robust signature discovery and assignments from whole exome and genome datasets (Jin, Gulhan et al Nat Genet. 2024). Her recent work focuses on understanding the immunogenomic and molecular characteristics of tumors with repair deficiencies. Her research program is dedicated to developing a comprehensive suite of tools for deciphering cancer genomes, aimed at personalized oncology. This includes the creation of statistical and machine-learning methods designed specifically for mutational signature analysis, clinical patient classification and tumor evolution inference.
Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer.
Authors: Perez-Villatoro F, Oikkonen J, Casado J, Chernenko A, Gulhan DC, Tumiati M, Li Y, Lavikka K, Hietanen S, Hynninen J, Haltia UM, Tyrmi JS, Laivuori H, Konstantinopoulos PA, Hautaniemi S, Kauppi L, Färkkilä A.
NPJ Precis Oncol
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NPJ Precis Oncol
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Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers.
Authors: Batalini F, Gulhan DC, Mao V, Tran A, Polak M, Xiong N, Tayob N, Tung NM, Winer EP, Mayer EL, Knappskog S, Lønning PE, Matulonis UA, Konstantinopoulos PA, Solit DB, Won H, Eikesdal HP, Park PJ, Wulf GM.
Clin Cancer Res
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Clin Cancer Res
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Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements.
Authors: Luquette LJ, Miller MB, Zhou Z, Bohrson CL, Zhao Y, Jin H, Gulhan D, Ganz J, Bizzotto S, Kirkham S, Hochepied T, Libert C, Galor A, Kim J, Lodato MA, Garaycoechea JI, Gawad C, West J, Walsh CA, Park PJ.
Nat Genet
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Nat Genet
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Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.
Authors: Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A.
Science
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Science
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Computational analysis of cancer genome sequencing data.
Authors: Cortés-Ciriano I, Gulhan DC, Lee JJ, Melloni GEM, Park PJ.
Nat Rev Genet
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Nat Rev Genet
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Similarity of gaze patterns across physical and virtual versions of an installation artwork.
A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer.
Authors: Konstantinopoulos PA, da Costa AABA, Gulhan D, Lee EK, Cheng SC, Hendrickson AEW, Kochupurakkal B, Kolin DL, Kohn EC, Liu JF, Stover EH, Curtis J, Tayob N, Polak M, Chowdhury D, Matulonis UA, Färkkilä A, D'Andrea AD, Shapiro GI.
Nat Commun
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Nat Commun
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Observation of Forward Neutron Multiplicity Dependence of Dimuon Acoplanarity in Ultraperipheral Pb-Pb Collisions at sqrt[s_{NN}]=5.02??TeV.
Authors: Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Erö J, Escalante Del Valle A, Frühwirth R, Jeitler M, Krammer N, Lechner L, Liko D, Madlener T, Mikulec I, Pitters FM, Rad N, Schieck J, Schöfbeck R, Spanring M, Templ S, Waltenberger W, Wulz CE, Zarucki M, Chekhovsky V, Litomin A, Makarenko V, Suarez Gonzalez J, Darwish MR, De Wolf EA, Di Croce D, Janssen X, Kello T, Lelek A, Pieters M, Rejeb Sfar H, Van Haevermaet H, Van Mechelen P, Van Putte S, Van Remortel N, Blekman F, Bols ES, Chhibra SS, D'Hondt J, De Clercq J, Lontkovskyi D, Lowette S, Marchesini I, Moortgat S, Morton A, Python Q, Tavernier S, Van Doninck W, Van Mulders P, Beghin D, Bilin B, Clerbaux B, De Lentdecker G, Dorney B, Favart L, Grebenyuk A, Kalsi AK, Makarenko I, Moureaux L, Pétré L, Popov A, Postiau N, Starling E, Thomas L, Vander Velde C, Vanlaer P, Vannerom D, Wezenbeek L, Cornelis T, Dobur D, Gruchala M, Khvastunov I, Niedziela M, Roskas C, Skovpen K, Tytgat M, Verbeke W, Vermassen B, Vit M, Bruno G, Bury F, Caputo C, David P, Delaere C, Delcourt M, Donertas IS, Giammanco A, Lemaitre V, Mondal K, Prisciandaro J, Taliercio A, Teklishyn M, Vischia P, Wuyckens S, Zobec J, Alves GA, Hensel C, Moraes A, Aldá Júnior WL, Belchior Batista Das Chagas E, Brandao Malbouisson H, Carvalho W, Chinellato J, Coelho E, Da Costa EM, Da Silveira GG, De Jesus Damiao D, Fonseca De Souza S, Martins J, Matos Figueiredo D, Medina Jaime M, Mora Herrera C, Mundim L, Nogima H, Rebello Teles P, Sanchez Rosas LJ, Santoro A, Silva Do Amaral SM, Sznajder A, Thiel M, Torres Da Silva De Araujo F, Vilela Pereira A, Bernardes CA, Calligaris L, Tomei TRFP, Gregores EM, Lemos DS, Mercadante PG, Novaes SF, Padula SS, Aleksandrov A, Antchev G, Atanasov I, Hadjiiska R, Iaydjiev P, Misheva M, Rodozov M, Shopova M, Sultanov G, Bonchev M, Dimitrov A, Ivanov T, Litov L, Pavlov B, Petkov P, Petrov A, Fang W, Guo Q, Wang H, Yuan L, Ahmad M, Hu Z, Wang Y, Chapon E, Chen GM, Chen HS, Chen M, Javaid T, Kapoor A, Leggat D, Liao H, Liu Z, Sharma R, Spiezia A, Tao J, Thomas-Wilsker J, Wang J, Zhang H, Zhang S, Zhao J, Agapitos A, Ban Y, Chen C, Huang Q, Levin A, Li Q, Lu M, Lyu X, Mao Y, Qian SJ, Wang D, Wang Q, Xiao J, You Z, Gao X, Xiao M, Avila C, Cabrera A, Florez C, Fraga J, Sarkar A, Segura Delgado MA, Jaramillo J, Mejia Guisao J, Ramirez F, Ruiz Alvarez JD, Salazar González CA, Vanegas Arbelaez N, Giljanovic D, Godinovic N, Lelas D, Puljak I, Sculac T, Antunovic Z, Kovac M, Brigljevic V, Ferencek D, Majumder D, Roguljic M, Starodumov A, Susa T, Ather MW, Attikis A, Erodotou E, Ioannou A, Kole G, Kolosova M, Konstantinou S, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Saka H, Tsiakkouri D, Finger M, Finger M, Kveton A, Tomsa J, Ayala E, Carrera Jarrin E, Elgammal S, Ellithi Kamel A, Mohamed A, Mahmoud MA, Mohammed Y, Bhowmik S, Carvalho Antunes De Oliveira A, Dewanjee RK, Ehataht K, Kadastik M, Raidal M, Veelken C, Eerola P, Forthomme L, Kirschenmann H, Osterberg K, Voutilainen M, Brücken E, Garcia F, Havukainen J, Karimäki V, Kim MS, Kinnunen R, Lampén T, Lassila-Perini K, Laurila S, Lehti S, Lindén T, Siikonen H, Tuominen E, Tuominiemi J, Luukka P, Tuuva T, Amendola C, Besancon M, Couderc F, Dejardin M, Denegri D, Faure JL, Ferri F, Ganjour S, Givernaud A, Gras P, Hamel de Monchenault G, Jarry P, Lenzi B, Locci E, Malcles J, Rander J, Rosowsky A, Sahin MÖ, Savoy-Navarro A, Titov M, Yu GB, Ahuja S, Beaudette F, Bonanomi M, Buchot Perraguin A, Busson P, Charlot C, Davignon O, Diab B, Falmagne G, Granier de Cassagnac R, Hakimi A, Kucher I, Lobanov A, Martin Perez C, Nguyen M, Ochando C, Paganini P, Rembser J, Salerno R, Sauvan JB, Sirois Y, Zabi A, Zghiche A, Agram JL, Andrea J, Bloch D, Bourgatte G, Brom JM, Chabert EC, Collard C, Fontaine JC, Gelé D, Goerlach U, Grimault C, Le Bihan AC, Van Hove P, Asilar E, Beauceron S, Bernet C, Boudoul G, Camen C, Carle A, Chanon N, Contardo D, Depasse P, El Mamouni H, Fay J, Gascon S, Gouzevitch M, Ille B, et al.
Phys Rev Lett
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Phys Rev Lett
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Constraints on the Initial State of Pb-Pb Collisions via Measurements of Z-Boson Yields and Azimuthal Anisotropy at sqrt[s_{NN}]=5.02??TeV.
Authors: Sirunyan AM, Tumasyan A, Adam W, Ambrogi F, Bergauer T, Dragicevic M, Erö J, Escalante Del Valle A, Frühwirth R, Jeitler M, Krammer N, Lechner L, Liko D, Madlener T, Mikulec I, Pitters FM, Rad N, Schieck J, Schöfbeck R, Spanring M, Templ S, Waltenberger W, Wulz CE, Zarucki M, Chekhovsky V, Litomin A, Makarenko V, Suarez Gonzalez J, Darwish MR, De Wolf EA, Di Croce D, Janssen X, Kello T, Lelek A, Pieters M, Rejeb Sfar H, Van Haevermaet H, Van Mechelen P, Van Putte S, Van Remortel N, Blekman F, Bols ES, Chhibra SS, D'Hondt J, De Clercq J, Lontkovskyi D, Lowette S, Marchesini I, Moortgat S, Morton A, Python Q, Tavernier S, Van Doninck W, Van Mulders P, Beghin D, Bilin B, Clerbaux B, De Lentdecker G, Dorney B, Favart L, Grebenyuk A, Kalsi AK, Makarenko I, Moureaux L, Pétré L, Popov A, Postiau N, Starling E, Thomas L, Vander Velde C, Vanlaer P, Vannerom D, Wezenbeek L, Cornelis T, Dobur D, Gruchala M, Khvastunov I, Niedziela M, Roskas C, Skovpen K, Tytgat M, Verbeke W, Vermassen B, Vit M, Bruno G, Bury F, Caputo C, David P, Delaere C, Delcourt M, Donertas IS, Giammanco A, Lemaitre V, Mondal K, Prisciandaro J, Taliercio A, Teklishyn M, Vischia P, Wuyckens S, Zobec J, Alves GA, Correia Silva G, Hensel C, Moraes A, Aldá Júnior WL, Belchior Batista Das Chagas E, Brandao Malbouisson H, Carvalho W, Chinellato J, Coelho E, Da Costa EM, Da Silveira GG, De Jesus Damiao D, Fonseca De Souza S, Martins J, Matos Figueiredo D, Medina Jaime M, Melo De Almeida M, Mora Herrera C, Mundim L, Nogima H, Rebello Teles P, Sanchez Rosas LJ, Santoro A, Silva Do Amaral SM, Sznajder A, Thiel M, Tonelli Manganote EJ, Torres Da Silva De Araujo F, Vilela Pereira A, Bernardes CA, Calligaris L, Tomei TRFP, Gregores EM, Lemos DS, Mercadante PG, Novaes SF, Padula SS, Aleksandrov A, Antchev G, Atanasov I, Hadjiiska R, Iaydjiev P, Misheva M, Rodozov M, Shopova M, Sultanov G, Bonchev M, Dimitrov A, Ivanov T, Litov L, Pavlov B, Petkov P, Petrov A, Fang W, Guo Q, Wang H, Yuan L, Ahmad M, Hu Z, Wang Y, Chapon E, Chen GM, Chen HS, Chen M, Kapoor A, Leggat D, Liao H, Liu Z, Sharma R, Spiezia A, Tao J, Thomas-Wilsker J, Wang J, Zhang H, Zhang S, Zhao J, Agapitos A, Ban Y, Chen C, Huang Q, Levin A, Li Q, Lu M, Lyu X, Mao Y, Qian SJ, Wang D, Wang Q, Xiao J, You Z, Gao X, Xiao M, Avila C, Cabrera A, Florez C, Fraga J, Sarkar A, Segura Delgado MA, Jaramillo J, Mejia Guisao J, Ramirez F, Ruiz Alvarez JD, Salazar González CA, Vanegas Arbelaez N, Giljanovic D, Godinovic N, Lelas D, Puljak I, Sculac T, Antunovic Z, Kovac M, Brigljevic V, Ferencek D, Majumder D, Roguljic M, Starodumov A, Susa T, Ather MW, Attikis A, Erodotou E, Ioannou A, Kole G, Kolosova M, Konstantinou S, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Saka H, Tsiakkouri D, Finger M, Finger M, Kveton A, Tomsa J, Ayala E, Carrera Jarrin E, Abu Zeid S, Assran Y, Mohamed A, Lotfy A, Mahmoud MA, Bhowmik S, Carvalho Antunes De Oliveira A, Dewanjee RK, Ehataht K, Kadastik M, Raidal M, Veelken C, Eerola P, Forthomme L, Kirschenmann H, Osterberg K, Voutilainen M, Brücken E, Garcia F, Havukainen J, Karimäki V, Kim MS, Kinnunen R, Lampén T, Lassila-Perini K, Laurila S, Lehti S, Lindén T, Siikonen H, Tuominen E, Tuominiemi J, Luukka P, Tuuva T, Amendola C, Besancon M, Couderc F, Dejardin M, Denegri D, Faure JL, Ferri F, Ganjour S, Givernaud A, Gras P, Hamel de Monchenault G, Jarry P, Lenzi B, Locci E, Malcles J, Rander J, Rosowsky A, Sahin MÖ, Savoy-Navarro A, Titov M, Yu GB, Ahuja S, Beaudette F, Bonanomi M, Buchot Perraguin A, Busson P, Charlot C, Davignon O, Diab B, Falmagne G, Granier de Cassagnac R, Hakimi A, Kucher I, Lobanov A, Martin Perez C, Nguyen M, Ochando C, Paganini P, Rembser J, Salerno R, Sauvan JB, Sirois Y, Zabi A, Zghiche A, Agram JL, Andrea J, Bloch D, Bourgatte G, Brom JM, Chabert EC, Collard C, Fontaine JC, Gelé D, Goerlach U, Grimault C, Le Bihan AC, Van Hove P, Asilar E, Beauceron S, Bernet C, Boudoul G, Camen C, Carle A, Chanon N, Contardo D, Depasse P, et al.
Phys Rev Lett
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Phys Rev Lett
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Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells.
Authors: Färkkilä A, Rodríguez A, Oikkonen J, Gulhan DC, Nguyen H, Domínguez J, Ramos S, Mills CE, Pérez-Villatoro F, Lazaro JB, Zhou J, Clairmont CS, Moreau LA, Park PJ, Sorger PK, Hautaniemi S, Frias S, D'Andrea AD.
Cancer Res
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Cancer Res
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