Griffin Weber

Griffin Weber, MD, PhD

Associate Professor of Medicine, Beth Israel Deaconess Medical Center
Associate Professor of Biomedical Informatics, Harvard Medical School (Secondary)

Griffin Weber directs the Biomedical Research Informatics Core (BRIC) at BIDMC. A result of his research in expertise mining and social network analysis is his invention of an open source social networking website for scientists called Profiles RNS, now used at dozens of universities across the country. It automatically mines large datasets such as PubMed, NIH ExPORTER, and the U.S. patent database to discover investigators' research areas and scientific networks. It then presents these connections using temporal, geospatial, and network visualizations. The software has numerous applications, ranging from finding individual collaborators and mentors to understanding the dynamics of an entire research community.

Weber is also an investigator on Informatics for Integrating Biology and the Bedside (i2b2), an NIH National Center for Biomedical Computing, for which he helped developed a web-based open source platform that enables a variety of functions, including queries of large clinical repositories for hypothesis testing and identification of patients for clinical trials. He also created the original prototype software for the Shared Health Research Information Network (SHRINE), which is a federated query tool that connects i2b2 databases across multiple institutions. More than 100 institutions worldwide use i2b2 and SHRINE to support clinical research.

Weber received his M.D. and Ph.D. in computer science from Harvard University in 2007. While still a student, he became the first Chief Technology Officer of Harvard Medical School and built an educational web portal that provides interactive online content to over 500 courses. His past research projects also include analyzing DNA microarrays, modeling the growth of breast cancer tumors, and creating algorithms for predicting life expectancy.

Predicting the higher rate of intracranial hemorrhage in glioma patients receiving therapeutic enoxaparin.
Authors: Mantia C, Uhlmann EJ, Puligandla M, Weber GM, Neuberg D, Zwicker JI.
Blood
View full abstract on Pubmed
Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins.
Authors: Hauser TH, Salastekar N, Schaefer EJ, Desai T, Goldfine HL, Fowler KM, Weber GM, Welty F, Clouse M, Shoelson SE, Goldfine AB.
JAMA Cardiol
View full abstract on Pubmed
Faculty Promotion and Attrition: The Importance of Coauthor Network Reach at an Academic Medical Center.
Authors: Warner ET, Carapinha R, Weber GM, Hill EV, Reede JY.
J Gen Intern Med
View full abstract on Pubmed
Considering context in academic medicine: differences in demographic and professional characteristics and in research productivity and advancement metrics across seven clinical departments.
Authors: Warner ET, Carapinha R, Weber GM, Hill EV, Reede JY.
Acad Med
View full abstract on Pubmed
Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study.
Authors: Donato J, Campigotto F, Uhlmann EJ, Coletti E, Neuberg D, Weber GM, Zwicker JI.
Blood
View full abstract on Pubmed
Federated queries of clinical data repositories: Scaling to a national network.
Authors: Weber GM.
J Biomed Inform
View full abstract on Pubmed
Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture.
Authors: Mandl KD, Kohane IS, McFadden D, Weber GM, Natter M, Mandel J, Schneeweiss S, Weiler S, Klann JG, Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, Murphy SN.
J Am Med Inform Assoc
View full abstract on Pubmed
Query Health: standards-based, cross-platform population health surveillance.
Authors: Klann JG, Buck MD, Brown J, Hadley M, Elmore R, Weber GM, Murphy SN.
J Am Med Inform Assoc
View full abstract on Pubmed
Finding the missing link for big biomedical data.
Authors: Weber GM, Mandl KD, Kohane IS.
JAMA
View full abstract on Pubmed
The use and significance of a research networking system.
Authors: Kahlon M, Yuan L, Daigre J, Meeks E, Nelson K, Piontkowski C, Reuter K, Sak R, Turner B, Weber GM, Chatterjee A.
J Med Internet Res
View full abstract on Pubmed