Ofer Isakov

Ofer Isakov, MD, PhD

Berkowitz Family Living Laboratory Postdoctoral Research Fellow

Ofer Isakov is a physician-scientist with a specialty in internal medicine. Ofer is a graduate of the MD/PhD program in Tel Aviv University. His doctoral dissertation focused on the development and application of bioinformatics tools to study human and microbial genomics. During his residency, Ofer led a bioinformatics lab at the Tel Aviv Medical Center, which focused on applying machine learning methods to study clinical questions. Ofer serves as the head of bioinformatics at the genomics center in Clalit. His responsibilities include conception, incorporation and validation of the methods, tools and infrastructure required for analysis of genomic data. Ofer’s research interests include rare genetic disease diagnosis, characterization of genotype-phenotype associations and development of novel genomic data science methods.

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.
Authors: Samuelov L, Sarig O, Harmon RM, Rapaport D, Ishida-Yamamoto A, Isakov O, Koetsier JL, Gat A, Goldberg I, Bergman R, Spiegel R, Eytan O, Geller S, Peleg S, Shomron N, Goh CSM, Wilson NJ, Smith FJD, Pohler E, Simpson MA, McLean WHI, Irvine AD, Horowitz M, McGrath JA, Green KJ, Sprecher E.
Nat Genet
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Missense mutation in the MEN1 gene discovered through whole exome sequencing co-segregates with familial hyperparathyroidism.
Authors: Isakov O, Rinella ES, Olchovsky D, Shimon I, Ostrer H, Shomron N, Friedman E.
Genet Res (Camb)
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Meeting summary: Ethical aspects of whole exome and whole genome sequencing studies (WES/WGS) in rare diseases, Tel Aviv, Israel, January 2013.
Authors: Farberov L, Gilam A, Isakov O, Shomron N.
Genet Res (Camb)
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Analysis of insertion-deletion from deep-sequencing data: software evaluation for optimal detection.
Authors: Neuman JA, Isakov O, Shomron N.
Brief Bioinform
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Exome sequencing analysis: a guide to disease variant detection.
Authors: Isakov O, Perrone M, Shomron N.
Methods Mol Biol
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Analysis of insertion-deletion from deep-sequencing data: software evaluation for optimal detection.
Authors: Neuman JA, Isakov O, Shomron N.
Brief Bioinform
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Vaccinia virus infection suppresses the cell microRNA machinery.
Authors: Grinberg M, Gilad S, Meiri E, Levy A, Isakov O, Ronen R, Shomron N, Bentwich Z, Shemer-Avni Y.
Arch Virol
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Familial pityriasis rubra pilaris is caused by mutations in CARD14.
Authors: Fuchs-Telem D, Sarig O, van Steensel MA, Isakov O, Israeli S, Nousbeck J, Richard K, Winnepenninckx V, Vernooij M, Shomron N, Uitto J, Fleckman P, Richard G, Sprecher E.
Am J Hum Genet
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Novel insight into the non-coding repertoire through deep sequencing analysis.
Authors: Isakov O, Ronen R, Kovarsky J, Gabay A, Gan I, Modai S, Shomron N.
Nucleic Acids Res
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miRviewer: a multispecies microRNA homologous viewer.
Authors: Kiezun A, Artzi S, Modai S, Volk N, Isakov O, Shomron N.
BMC Res Notes
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