Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for genome analysis, especially for identification of structural alterations from whole-genome sequencing data, and has made substantial contributions to consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome (4DN).


DBMI Research Areas
DBMI Courses
Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types.
Authors: Day DS, Zhang B, Stevens SM, Ferrari F, Larschan EN, Park PJ, Pu WT.
Genome Biol
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Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies.
Authors: Lee JK, Choi YL, Kwon M, Park PJ.
Annu Rev Pathol
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Next-generation sequencing-based detection of germline L1-mediated transductions.
Authors: Tica J, Lee E, Untergasser A, Meiers S, Garfield DA, Gokcumen O, Furlong EE, Park PJ, Stütz AM, Korbel JO.
BMC Genomics
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MNase titration reveals differences between nucleosome occupancy and chromatin accessibility.
Authors: Mieczkowski J, Cook A, Bowman SK, Mueller B, Alver BH, Kundu S, Deaton AM, Urban JA, Larschan E, Park PJ, Kingston RE, Tolstorukov MY.
Nat Commun
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Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing.
Authors: Yang L, Lee MS, Lu H, Oh DY, Kim YJ, Park D, Park G, Ren X, Bristow CA, Haseley PS, Lee S, Pantazi A, Kucherlapati R, Park WY, Scott KL, Choi YL, Park PJ.
Am J Hum Genet
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Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors.
Authors: Ordulu Z, Nucci MR, Dal Cin P, Hollowell ML, Otis CN, Hornick JL, Park PJ, Kim TM, Quade BJ, Morton CC.
Mod Pathol
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Corrigendum: Failure to replicate the STAP cell phenomenon.
Authors: De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ.
Nature
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Corrigendum: Hallmarks of pluripotency.
Authors: De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ.
Nature
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Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.
Authors: Chen F, Zhang Y, Senbabaoglu Y, Ciriello G, Yang L, Reznik E, Shuch B, Micevic G, De Velasco G, Shinbrot E, Noble MS, Lu Y, Covington KR, Xi L, Drummond JA, Muzny D, Kang H, Lee J, Tamboli P, Reuter V, Shelley CS, Kaipparettu BA, Bottaro DP, Godwin AK, Gibbs RA, Getz G, Kucherlapati R, Park PJ, Sander C, Henske EP, Zhou JH, Kwiatkowski DJ, Ho TH, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJ.
Cell Rep
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Evaluation of somatic copy number estimation tools for whole-exome sequencing data.
Authors: Nam JY, Kim NK, Kim SC, Joung JG, Xi R, Lee S, Park PJ, Park WY.
Brief Bioinform
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