Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Diverse mechanisms of somatic structural variations in human cancer genomes.
Authors: Yang L, Luquette LJ, Gehlenborg N, Xi R, Haseley PS, Hsieh CH, Zhang C, Ren X, Protopopov A, Chin L, Kucherlapati R, Lee C, Park PJ.
Cell
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Integrated genomic characterization of endometrial carcinoma.
Authors: Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC, Yau C, Laird PW, Ding L, Zhang W, Mills GB, Kucherlapati R, Mardis ER, Levine DA.
Nature
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Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".
Authors: Ferrari F, Jung YL, Kharchenko PV, Plachetka A, Alekseyenko AA, Kuroda MI, Park PJ.
Science
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Nozzle: a report generation toolkit for data analysis pipelines.
Authors: Gehlenborg N, Noble MS, Getz G, Chin L, Park PJ.
Bioinformatics
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Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila.
Authors: Alekseyenko AA, Ellison CE, Gorchakov AA, Zhou Q, Kaiser VB, Toda N, Walton Z, Peng S, Park PJ, Bachtrog D, Kuroda MI.
Genes Dev
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KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.
Authors: Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ, Bardeesy N.
J Clin Invest
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Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes.
Authors: Kim TM, Xi R, Luquette LJ, Park RW, Johnson MD, Park PJ.
Genome Res
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The Stem Cell Commons: an exemplar for data integration in the biomedical domain driven by the ISA framework.
Authors: Ho Sui S, Merrill E, Gehlenborg N, Haseley P, Sytchev I, Park R, Rocca-Serra P, Corlosquet S, Gonzalez-Beltran A, Maguire E, Hofmann O, Park P, Das S, Sansone SA, Hide W.
AMIA Jt Summits Transl Sci Proc
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The HL7 standards-based model of emergency care information.
Authors: McClay J, Park P, Marr SD, Langford LH.
Stud Health Technol Inform
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Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1a.
Authors: Kim YJ, Lee HJ, Kim TM, Eisinger-Mathason TS, Zhang AY, Schmidt B, Karl DL, Nakazawa MS, Park PJ, Simon MC, Yoon SS.
Int J Cancer
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