Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma.
Authors: Yang HW, Kim TM, Song SS, Shrinath N, Park R, Kalamarides M, Park PJ, Black PM, Carroll RS, Johnson MD.
Neoplasia
View full abstract on Pubmed
Advances in analysis of transcriptional regulatory networks.
Authors: Kim TM, Park PJ.
Wiley Interdiscip Rev Syst Biol Med
View full abstract on Pubmed
Evidence for dosage compensation between the X chromosome and autosomes in mammals.
Authors: Kharchenko PV, Xi R, Park PJ.
Nat Genet
View full abstract on Pubmed
Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion.
Authors: Xi R, Hadjipanayis AG, Luquette LJ, Kim TM, Lee E, Zhang J, Johnson MD, Muzny DM, Wheeler DA, Gibbs RA, Kucherlapati R, Park PJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas.
Authors: Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, Delaney TF.
Int J Radiat Oncol Biol Phys
View full abstract on Pubmed
Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.
Authors: Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, Jäger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF.
Cell Stem Cell
View full abstract on Pubmed
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Authors: Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME.
Cell Metab
View full abstract on Pubmed
A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs.
Authors: Kim TM, Huang W, Park R, Park PJ, Johnson MD.
Cancer Res
View full abstract on Pubmed
Impact of chromatin structure on sequence variability in the human genome.
Authors: Tolstorukov MY, Volfovsky N, Stephens RM, Park PJ.
Nat Struct Mol Biol
View full abstract on Pubmed
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster.
Authors: Kharchenko PV, Alekseyenko AA, Schwartz YB, Minoda A, Riddle NC, Ernst J, Sabo PJ, Larschan E, Gorchakov AA, Gu T, Linder-Basso D, Plachetka A, Shanower G, Tolstorukov MY, Luquette LJ, Xi R, Jung YL, Park RW, Bishop EP, Canfield TK, Sandstrom R, Thurman RE, MacAlpine DM, Stamatoyannopoulos JA, Kellis M, Elgin SC, Kuroda MI, Pirrotta V, Karpen GH, Park PJ.
Nature
View full abstract on Pubmed