Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Network-based analysis of affected biological processes in type 2 diabetes models.
Authors: Liu M, Liberzon A, Kong SW, Lai WR, Park PJ, Kohane IS, Kasif S.
PLoS Genet
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Correlating breakage-fusion-bridge events with the overall chromosomal instability and in vitro karyotype evolution in prostate cancer.
Authors: Vukovic B, Beheshti B, Park P, Lim G, Bayani J, Zielenska M, Squire JA.
Cytogenet Genome Res
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A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma.
Authors: Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD.
Cancer Res
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Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression.
Authors: Yoon SS, Segal NH, Park PJ, Detwiller KY, Fernando NT, Ryeom SW, Brennan MF, Singer S.
J Surg Res
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A multivariate approach for integrating genome-wide expression data and biological knowledge.
Authors: Kong SW, Pu WT, Park PJ.
Bioinformatics
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A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies.
Authors: Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK.
Nat Biotechnol
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Postmeiotic sex chromatin in the male germline of mice.
Authors: Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT.
Curr Biol
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High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome.
Authors: Alekseyenko AA, Larschan E, Lai WR, Park PJ, Kuroda MI.
Genes Dev
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MSL complex associates with clusters of actively transcribed genes along the Drosophila male X chromosome.
Authors: Larschan E, Alekseyenko AA, Lai WR, Park PJ, Kuroda MI.
Cold Spring Harb Symp Quant Biol
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Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster.
Authors: Hamada FN, Park PJ, Gordadze PR, Kuroda MI.
Genes Dev
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