Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Park Lab

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for genome analysis, especially for identification of structural alterations from whole-genome sequencing data, and has made substantial contributions to consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome (4DN).


DBMI Research Areas
DBMI Courses
Essential histone chaperones collaborate to regulate transcription and chromatin integrity.
Authors: Viktorovskaya O, Chuang J, Jain D, Reim NI, López-Rivera F, Murawska M, Spatt D, Churchman LS, Park PJ, Winston F.
Genes Dev
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Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation.
Authors: Robinson DCL, Ritso M, Nelson GM, Mokhtari Z, Nakka K, Bandukwala H, Goldman SR, Park PJ, Mounier R, Chazaud B, Brand M, Rudnicki MA, Adelman K, Dilworth FJ.
Dev Cell
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Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing.
Authors: Rodin RE, Dou Y, Kwon M, Sherman MA, D'Gama AM, Doan RN, Rento LM, Girskis KM, Bohrson CL, Kim SN, Nadig A, Luquette LJ, Gulhan DC, Park PJ, Walsh CA.
Nat Neurosci
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Resources and challenges for integrative analysis of nuclear architecture data.
Authors: Jung YL, Kirli K, Alver BH, Park PJ.
Curr Opin Genet Dev
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Comprehensive identification of somatic nucleotide variants in human brain tissue.
Authors: Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, Yang X, Zhou B, Akbarian S, Ball LL, Bizzotto S, Emery SB, Doan R, Fasching L, Jang Y, Juan D, Lizano E, Luquette LJ, Moldovan JB, Narurkar R, Oetjens MT, Rodin RE, Sekar S, Shin JH, Soriano E, Straub RE, Zhou W, Chess A, Gleeson JG, Marquès-Bonet T, Park PJ, Peters MA, Pevsner J, Walsh CA, Weinberger DR, Vaccarino FM, Moran JV, Urban AE, Kidd JM, Mills RE, Abyzov A.
Genome Biol
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Exertional hypoxia in patients without resting hypoxia is an early predictor of moderate to severe COVID-19.
Authors: Bhasin A, Bregger M, Kluk M, Park P, Feinglass J, Barsuk J.
Intern Emerg Med
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The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.
Authors: Cook JH, Melloni GEM, Gulhan DC, Park PJ, Haigis KM.
Nat Commun
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Landmarks of human embryonic development inscribed in somatic mutations.
Authors: Bizzotto S, Dou Y, Ganz J, Doan RN, Kwon M, Bohrson CL, Kim SN, Bae T, Abyzov A, Park PJ, Walsh CA.
Science
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Deletions in CWH43 cause idiopathic normal pressure hydrocephalus.
Authors: Yang HW, Lee S, Yang D, Dai H, Zhang Y, Han L, Zhao S, Zhang S, Ma Y, Johnson MF, Rattray AK, Johnson TA, Wang G, Zheng S, Carroll RS, Park PJ, Johnson MD.
EMBO Mol Med
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The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing.
Authors: Rodin RE, Dou Y, Kwon M, Sherman MA, D'Gama AM, Doan RN, Rento LM, Girskis KM, Bohrson CL, Kim SN, Nadig A, Luquette LJ, Gulhan DC, Park PJ, Walsh CA.
Nat Neurosci
View full abstract on Pubmed