Ryan McGinty

Ryan McGinty, PhD

Research Fellow in Biomedical Informatics
Sunyaev Lab
Mentor: Shamil Sunyaev, PhD

Ryan McGinty received his PhD from Tufts University in the laboratory of Sergei Mirkin, studying microsatellite repeat expansion and complex genomic rearrangements. Current interests involve combining computational and experimental approaches to uncover mechanisms of mutagenesis in humans, especially those involving unusual DNA secondary structures.

Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures.
Authors: Hisey JA, Radchenko EA, Mandel NH, McGinty RJ, Matos-Rodrigues G, Rastokina A, Masnovo C, Ceschi S, Hernandez A, Nussenzweig A, Mirkin SM.
Nucleic Acids Res
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Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures.
Authors: Hisey JA, Radchenko EA, Ceschi S, Rastokina A, Mandel NH, McGinty RJ, Matos-Rodrigues G, Hernandez A, Nussenzweig A, Mirkin SM.
bioRxiv
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Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements.
Authors: Qi L, Sui Y, Tang XX, McGinty RJ, Liang XZ, Dominska M, Zhang K, Mirkin SM, Zheng DQ, Petes TD.
PLoS Genet
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Population sequencing data reveal a compendium of mutational processes in the human germ line.
Authors: Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de Las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS, Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S.
Science
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Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging.
Authors: Neil AJ, Hisey JA, Quasem I, McGinty RJ, Hitczenko M, Khristich AN, Mirkin SM.
Proc Natl Acad Sci U S A
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Cis- and Trans-Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics.
Authors: McGinty RJ, Mirkin SM.
Trends Genet
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Quantitative Analysis of the Rates for Repeat-Mediated Genome Instability in a Yeast Experimental System.
Authors: Radchenko EA, McGinty RJ, Aksenova AY, Neil AJ, Mirkin SM.
Methods Mol Biol
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Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair.
Authors: McGinty RJ, Rubinstein RG, Neil AJ, Dominska M, Kiktev D, Petes TD, Mirkin SM.
Genome Res
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A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich's Ataxia.
Authors: McGinty RJ, Puleo F, Aksenova AY, Hisey JA, Shishkin AA, Pearson EL, Wang ET, Housman DE, Moore C, Mirkin SM.
Cell Rep
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Coupling transcriptional state to large-scale repeat expansions in yeast.
Authors: Shah KA, McGinty RJ, Egorova VI, Mirkin SM.
Cell Rep
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