Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.
Authors: Kryukov GV, Pennacchio LA, Sunyaev SR.
Am J Hum Genet
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Medical sequencing at the extremes of human body mass.
Authors: Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA.
Am J Hum Genet
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Error-tolerant EST database searches by tandem mass spectrometry and multiTag software.
Authors: Liska AJ, Sunyaev S, Shilov IN, Schaeffer DA, Shevchenko A.
Proteomics
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Evolutionary constraints in conserved nongenic sequences of mammals.
Authors: Keightley PD, Kryukov GV, Sunyaev S, Halligan DL, Gaffney DJ.
Genome Res
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Small fitness effect of mutations in highly conserved non-coding regions.
Authors: Kryukov GV, Schmidt S, Sunyaev S.
Hum Mol Genet
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A universal trend of amino acid gain and loss in protein evolution.
Authors: Jordan IK, Kondrashov FA, Adzhubei IA, Wolf YI, Koonin EV, Kondrashov AS, Sunyaev S.
Nature
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Biocomputing enters its adolescence.
Authors: Sunyaev S.
Genome Biol
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Inferring SNP function using evolutionary, structural, and computational methods.
Authors: Dimmic MW, Sunyaev S, Bustamante CD.
Pac Symp Biocomput
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A limited role for balancing selection.
Authors: Asthana S, Schmidt S, Sunyaev S.
Trends Genet
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Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome.
Authors: Liska AJ, Popov AV, Sunyaev S, Coughlin P, Habermann B, Shevchenko A, Bork P, Karsenti E, Shevchenko A.
Proteomics
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