Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Indel-based evolutionary distance and mouse-human divergence.
Authors: Ogurtsov AY, Sunyaev S, Kondrashov AS.
Genome Res
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Positive selection at sites of multiple amino acid replacements since rat-mouse divergence.
Authors: Bazykin GA, Kondrashov FA, Ogurtsov AY, Sunyaev S, Kondrashov AS.
Nature
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The power and the limitations of cross-species protein identification by mass spectrometry-driven sequence similarity searches.
Authors: Habermann B, Oegema J, Sunyaev S, Shevchenko A.
Mol Cell Proteomics
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From analysis of protein structural alignments toward a novel approach to align protein sequences.
Authors: Sunyaev SR, Bogopolsky GA, Oleynikova NV, Vlasov PK, Finkelstein AV, Roytberg MA.
Proteins
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Impact of selection, mutation rate and genetic drift on human genetic variation.
Authors: Sunyaev S, Kondrashov FA, Bork P, Ramensky V.
Hum Mol Genet
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Metabolites: a helping hand for pathway evolution?
Authors: Schmidt S, Sunyaev S, Bork P, Dandekar T.
Trends Biochem Sci
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MultiTag: multiple error-tolerant sequence tag search for the sequence-similarity identification of proteins by mass spectrometry.
Authors: Sunyaev S, Liska AJ, Golod A, Shevchenko A, Shevchenko A.
Anal Chem
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A model for statistical significance of local similarities in structure.
Authors: Stark A, Sunyaev S, Russell RB.
J Mol Biol
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Increase of functional diversity by alternative splicing.
Authors: Kriventseva EV, Koch I, Apweiler R, Vingron M, Bork P, Gelfand MS, Sunyaev S.
Trends Genet
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Nanoelectrospray tandem mass spectrometry and sequence similarity searching for identification of proteins from organisms with unknown genomes.
Authors: Shevchenko A, Sunyaev S, Liska A, Bork P, Shevchenko A.
Methods Mol Biol
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