Shawn Norman Murphy, M.D., Ph.D.

Shawn Murphy, MD, PhD

Professor of Neurology at MGH
Associate Professor of Biomedical Informatics, Harvard Medical School (Secondary)

6177247980

Shawn Murphy currently serves as the Director of Research Computing and Informatics at Partners Healthcare and Associate Director for the Laboratory of Computer Science at the Massachusetts General Hospital where he developed the Research Patient Data Registry (RPDR) for Partners Healthcare. This application, which serves over 5,000 investigators performing research using the hospital medical record, served as the test bed for his work with Zak Kohane in developing the open source Informatics for Integrating Biology and the Bedside (i2b2) software platform now operating at over 120 hospitals worldwide. Murphy’s contribution as chief architect of the i2b2 platform has served to strengthen the understanding of the metabolic and genetic underpinnings of complex diseases by developing an informatics framework to integrate data for clinical research from electronic health records.

Health data use, stewardship, and governance: ongoing gaps and challenges: a report from AMIA's 2012 Health Policy Meeting.
Authors: Hripcsak G, Bloomrosen M, FlatelyBrennan P, Chute CG, Cimino J, Detmer DE, Edmunds M, Embi PJ, Goldstein MM, Hammond WE, Keenan GM, Labkoff S, Murphy S, Safran C, Speedie S, Strasberg H, Temple F, Wilcox AB.
J Am Med Inform Assoc
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Thromboprophylaxis is associated with reduced post-hospitalization venous thromboembolic events in patients with inflammatory bowel diseases.
Authors: Ananthakrishnan AN, Cagan A, Gainer VS, Cheng SC, Cai T, Scoville E, Konijeti GG, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP.
Clin Gastroenterol Hepatol
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Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records.
Authors: Sinnott JA, Dai W, Liao KP, Shaw SY, Ananthakrishnan AN, Gainer VS, Karlson EW, Churchill S, Szolovits P, Murphy S, Kohane I, Plenge R, Cai T.
Hum Genet
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Stratification of risk for hospital admissions for injury related to fall: cohort study.
Authors: Castro VM, McCoy TH, Cagan A, Rosenfield HR, Murphy SN, Churchill SE, Kohane IS, Perlis RH.
BMJ
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Rare copy number variation in treatment-resistant major depressive disorder.
Authors: O'Dushlaine C, Ripke S, Ruderfer DM, Hamilton SP, Fava M, Iosifescu DV, Kohane IS, Churchill SE, Castro VM, Clements CC, Blumenthal SR, Murphy SN, Smoller JW, Perlis RH.
Biol Psychiatry
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Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease.
Authors: Ananthakrishnan AN, Cagan A, Gainer VS, Cheng SC, Cai T, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP.
J Crohns Colitis
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An electronic health records study of long-term weight gain following antidepressant use.
Authors: Blumenthal SR, Castro VM, Clements CC, Rosenfield HR, Murphy SN, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Smoller JW, Perlis RH.
JAMA Psychiatry
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Serum inflammatory markers and risk of colorectal cancer in patients with inflammatory bowel diseases.
Authors: Ananthakrishnan AN, Cheng SC, Cai T, Cagan A, Gainer VS, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP.
Clin Gastroenterol Hepatol
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Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls.
Authors: Liao KP, Diogo D, Cui J, Cai T, Okada Y, Gainer VS, Murphy SN, Gupta N, Mirel D, Ananthakrishnan AN, Szolovits P, Shaw SY, Raychaudhuri S, Churchill S, Kohane I, Karlson EW, Plenge RM.
Ann Rheum Dis
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Association between reduced plasma 25-hydroxy vitamin D and increased risk of cancer in patients with inflammatory bowel diseases.
Authors: Ananthakrishnan AN, Cheng SC, Cai T, Cagan A, Gainer VS, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP.
Clin Gastroenterol Hepatol
View full abstract on Pubmed