Soumya Raychaudhuri, M.D., Ph.D.

Soumya Raychaudhuri, MD, PhD

Professor of Medicine, Brigham and Women's Hospital
Professor of Biomedical Informatics, Harvard Medical School (Secondary)
Visiting Professor in Genetics, University of Manchester

Soumya Raychaudhuri serves as the Director for the Center for Data Sciences (BWH, HMS) and is appointed as an Associate Member at the Broad Institute. Additionally he is clinically active and sees patients at Brigham and Women’s Hospital Arthritis Center. After completing his MD/PhD at Stanford University, Raychaudhuri pursued clinical training in internal medicine, and then went on to pursue subspecialty training in rheumatology at Brigham and Women’s Hospital. He concurrently completed postdoctoral training in human genetics at the Broad Institute with Dr. Mark Daly. Since joining the faculty at Harvard Medical School in 2010, he has contributed to the understanding of the genetic basis of rheumatoid arthritis and other immune-mediated diseases. He has also been at the forefront of devising statistical and computational methods to localize genetic association signals to causal variants, and to interpret human genetic data in the context of functional information. He currently has active research programs in the human genetics and functional genomics of tuberculosis, type I diabetes, and rheumatoid arthritis, with a specific focus on using genomic strategies to understand CD4+ T cell biology.

HATK: HLA analysis toolkit.
Authors: Choi W, Luo Y, Raychaudhuri S, Han B.
Bioinformatics
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IFN-? and TNF-a drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.
Authors: Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, Donlin LT, Raychaudhuri S.
Genome Med
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Accurate imputation of human leukocyte antigens with CookHLA.
Authors: Cook S, Choi W, Lim H, Luo Y, Kim K, Jia X, Raychaudhuri S, Han B.
Nat Commun
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Population-specific causal disease effect sizes in functionally important regions impacted by selection.
Authors: Shi H, Gazal S, Kanai M, Koch EM, Schoech AP, Siewert KM, Kim SS, Luo Y, Amariuta T, Huang H, Okada Y, Raychaudhuri S, Sunyaev SR, Price AL.
Nat Commun
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How COVID-19 is changing rheumatology clinical practice.
Authors: Bonfá E, Gossec L, Isenberg DA, Li Z, Raychaudhuri S.
Nat Rev Rheumatol
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Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.
Authors: Amariuta T, Ishigaki K, Sugishita H, Ohta T, Koido M, Dey KK, Matsuda K, Murakami Y, Price AL, Kawakami E, Terao C, Raychaudhuri S.
Nat Genet
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Interactions Between Genome-Wide Genetic Factors and Smoking Influencing Risk of Systemic Lupus Erythematosus.
Authors: Cui J, Raychaudhuri S, Karlson EW, Speyer C, Malspeis S, Guan H, Sparks JA, Ni H, Liu X, Stevens E, Williams JN, Davenport EE, Knevel R, Costenbader KH.
Arthritis Rheumatol
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Genome-wide Study Identifies Association between HLA-B*55:01 and Self-Reported Penicillin Allergy.
Authors: Krebs K, Bovijn J, Zheng N, Lepamets M, Censin JC, Jürgenson T, Särg D, Abner E, Laisk T, Luo Y, Skotte L, Geller F, Feenstra B, Wang W, Auton A, Raychaudhuri S, Esko T, Metspalu A, Laur S, Roden DM, Wei WQ, Holmes MV, Lindgren CM, Phillips EJ, Mägi R, Milani L, Fadista J.
Am J Hum Genet
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IFN- ? and TNF- a drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.
Authors: Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, Donlin LT, Raychaudhuri S.
bioRxiv
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RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares.
Authors: Orange DE, Yao V, Sawicka K, Fak J, Frank MO, Parveen S, Blachere NE, Hale C, Zhang F, Raychaudhuri S, Troyanskaya OG, Darnell RB.
N Engl J Med
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