Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Detecting structural variations in the human genome using next generation sequencing.
Authors: Xi R, Kim TM, Park PJ.
Brief Funct Genomics
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Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.
Authors: Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M.
Nat Med
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[Dosage compensation in drosophila: sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome].
Authors: Gorchakov AA, Alekseenko AA, Kharchenko PV, Park P, Kuroda M.
Genetika
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rSW-seq: algorithm for detection of copy number alterations in deep sequencing data.
Authors: Kim TM, Luquette LJ, Xi R, Park PJ.
BMC Bioinformatics
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Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status.
Authors: Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ, Black PM, Giovannini M, Carroll RS, Kalamarides M.
Clin Cancer Res
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Quantized correlation coefficient for measuring reproducibility of ChIP-chip data.
Authors: Peng S, Kuroda MI, Park PJ.
BMC Bioinformatics
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Variation of telencephalon morphology of the threespine stickleback (Gasterosteus aculeatus) in relation to inferred ecology.
Authors: Park PJ, Bell MA.
J Evol Biol
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CpG islands recruit a histone H3 lysine 36 demethylase.
Authors: Blackledge NP, Zhou JC, Tolstorukov MY, Farcas AM, Park PJ, Klose RJ.
Mol Cell
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Analysis of primary structure of chromatin with next-generation sequencing.
Authors: Tolstorukov MY, Kharchenko PV, Park PJ.
Epigenomics
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Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship.
Authors: Kim H, Huang W, Jiang X, Pennicooke B, Park PJ, Johnson MD.
Proc Natl Acad Sci U S A
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