Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
A region of the human HOXD cluster that confers polycomb-group responsiveness.
Authors: Woo CJ, Kharchenko PV, Daheron L, Park PJ, Kingston RE.
Cell
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Estimating enrichment of repetitive elements from high-throughput sequence data.
Authors: Day DS, Luquette LJ, Park PJ, Kharchenko PV.
Genome Biol
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Integration of heterogeneous expression data sets extends the role of the retinol pathway in diabetes and insulin resistance.
Authors: Park PJ, Kong SW, Tebaldi T, Lai WR, Kasif S, Kohane IS.
Bioinformatics
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Long-range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X.
Authors: Gorchakov AA, Alekseyenko AA, Kharchenko P, Park PJ, Kuroda MI.
Genes Dev
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Identifying the molecular signature of the interstitial deletion 7q subgroup of uterine leiomyomata using a paired analysis.
Authors: Hodge JC, Park PJ, Dreyfuss JM, Assil-Kishawi I, Somasundaram P, Semere LG, Quade BJ, Lynch AM, Stewart EA, Morton CC.
Genes Chromosomes Cancer
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ChIP-seq: advantages and challenges of a maturing technology.
Authors: Park PJ.
Nat Rev Genet
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Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers.
Authors: Dreyfuss JM, Johnson MD, Park PJ.
Mol Cancer
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Thyroid hormone-related regulation of gene expression in human fatty liver.
Authors: Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME.
J Clin Endocrinol Metab
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Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.
Authors: Gelbart ME, Larschan E, Peng S, Park PJ, Kuroda MI.
Nat Struct Mol Biol
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Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.
Authors: Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG.
Int J Radiat Oncol Biol Phys
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