Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.
Authors: McKinney-Freeman SL, Naveiras O, Yates F, Loewer S, Philitas M, Curran M, Park PJ, Daley GQ.
Blood
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Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood.
Authors: Wang XP, O'Connell DJ, Lund JJ, Saadi I, Kuraguchi M, Turbe-Doan A, Cavallesco R, Kim H, Park PJ, Harada H, Kucherlapati R, Maas RL.
Development
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Comparative analysis of H2A.Z nucleosome organization in the human and yeast genomes.
Authors: Tolstorukov MY, Kharchenko PV, Goldman JA, Kingston RE, Park PJ.
Genome Res
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The MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila melanogaster X chromosome.
Authors: Sural TH, Peng S, Li B, Workman JL, Park PJ, Kuroda MI.
Nat Struct Mol Biol
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Design and analysis of ChIP-seq experiments for DNA-binding proteins.
Authors: Kharchenko PV, Tolstorukov MY, Park PJ.
Nat Biotechnol
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Aging elevates metabolic gene expression in brain cholinergic neurons.
Authors: Baskerville KA, Kent C, Personett D, Lai WR, Park PJ, Coleman P, McKinney M.
Neurobiol Aging
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Epigenetics meets next-generation sequencing.
Authors: Park PJ.
Epigenetics
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Experimental design and data analysis for array comparative genomic hybridization.
Authors: Park PJ.
Cancer Invest
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Nucleosome positioning in human HOX gene clusters.
Authors: Kharchenko PV, Woo CJ, Tolstorukov MY, Kingston RE, Park PJ.
Genome Res
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Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.
Authors: Dermody JL, Dreyfuss JM, Villén J, Ogundipe B, Gygi SP, Park PJ, Ponticelli AS, Moore CL, Buratowski S, Bucheli ME.
PLoS One
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