Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome.
Authors: Alekseyenko AA, Peng S, Larschan E, Gorchakov AA, Lee OK, Kharchenko P, McGrath SD, Wang CI, Mardis ER, Park PJ, Kuroda MI.
Cell
View full abstract on Pubmed
nuScore: a web-interface for nucleosome positioning predictions.
Authors: Tolstorukov MY, Choudhary V, Olson WK, Zhurkin VB, Park PJ.
Bioinformatics
View full abstract on Pubmed
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression.
Authors: Mueller JL, Mahadevaiah SK, Park PJ, Warburton PE, Page DC, Turner JM.
Nat Genet
View full abstract on Pubmed
Differential H3K4 methylation identifies developmentally poised hematopoietic genes.
Authors: Orford K, Kharchenko P, Lai W, Dao MC, Worhunsky DJ, Ferro A, Janzen V, Park PJ, Scadden DT.
Dev Cell
View full abstract on Pubmed
CGHweb: a tool for comparing DNA copy number segmentations from multiple algorithms.
Authors: Lai W, Choudhary V, Park PJ.
Bioinformatics
View full abstract on Pubmed
Integrative analysis reveals the direct and indirect interactions between DNA copy number aberrations and gene expression changes.
Authors: Lee H, Kong SW, Park PJ.
Bioinformatics
View full abstract on Pubmed
Pathway analysis of primary central nervous system lymphoma.
Authors: Tun HW, Personett D, Baskerville KA, Menke DM, Jaeckle KA, Kreinest P, Edenfield B, Zubair AC, O'Neill BP, Lai WR, Park PJ, McKinney M.
Blood
View full abstract on Pubmed
Specific genes expressed in association with progesterone receptors in meningioma.
Authors: Claus EB, Park PJ, Carroll R, Chan J, Black PM.
Cancer Res
View full abstract on Pubmed
MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism.
Authors: Larschan E, Alekseyenko AA, Gortchakov AA, Peng S, Li B, Yang P, Workman JL, Park PJ, Kuroda MI.
Mol Cell
View full abstract on Pubmed
Normalization and experimental design for ChIP-chip data.
Authors: Peng S, Alekseyenko AA, Larschan E, Kuroda MI, Park PJ.
BMC Bioinformatics
View full abstract on Pubmed