Vinay Viswanadham

Vinay Viswanadham, PhD

Research Fellow in Biomedical Informatics
Park Lab
Mentor: Peter Park, PhD

Vinay Viswanadham is a postdoctoral research fellow in the laboratory of Peter Park at Harvard Medical School, from which he received his PhD in Biomedical Informatics in May 2023. He completed his dissertation on the origins, patterns, and consequences of somatic mutations in cancer, brain development, and gene editing. He continues to study somatic mutations in these three settings by developing computational methods to detect somatic mutations from emerging technologies.

Polygenic risk scores for autoimmune related diseases are significantly different in cancer exceptional responders.
Authors: Chen S, Tan ALM, Saad Menezes MC, Mao JF, Perry CL, Vella ME, Viswanadham VV, Kobren S, Churchill S, Kohane IS.
NPJ Precis Oncol
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High-resolution detection of copy number alterations in single cells with HiScanner.
Authors: Zhao Y, Luquette LJ, Veit AD, Wang X, Xi R, Viswanadham VV, Shao DD, Walsh CA, Yang HW, Johnson MD, Park PJ.
bioRxiv
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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.
Authors: Ganz J, Luquette LJ, Bizzotto S, Miller MB, Zhou Z, Bohrson CL, Jin H, Tran AV, Viswanadham VV, McDonough G, Brown K, Chahine Y, Chhouk B, Galor A, Park PJ, Walsh CA.
Cell
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Predicting response to immune checkpoint blockade therapy among mismatch repair-deficient patients using mutational signatures.
Authors: Gulhan DC, Viswanadham V, Muyas F, Jin H, Foote MB, Lee JJ, Barras D, Jung YL, Ljungstrom V, Rousseau B, Galor A, Diplas BH, Maron SB, Cleary JM, Cortés-Ciriano I, Park PJ.
medRxiv
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Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex.
Authors: Kim SN, Viswanadham VV, Doan RN, Dou Y, Bizzotto S, Khoshkhoo S, Huang AY, Yeh R, Chhouk B, Truong A, Chappell KM, Beaudin M, Barton A, Akula SK, Rento L, Lodato M, Ganz J, Szeto RA, Li P, Tsai JW, Hill RS, Park PJ, Walsh CA.
bioRxiv
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ERa-associated translocations underlie oncogene amplifications in breast cancer.
Authors: Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ.
Nature
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Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.
Authors: Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A.
Science
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Comprehensive identification of transposable element insertions using multiple sequencing technologies.
Authors: Chu C, Borges-Monroy R, Viswanadham VV, Lee S, Li H, Lee EA, Park PJ.
Nat Commun
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B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers.
Authors: Mahajan VS, Mattoo H, Sun N, Viswanadham V, Yuen GJ, Allard-Chamard H, Ahmad M, Murphy SJH, Cariappa A, Tuncay Y, Pillai S.
Nat Commun
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DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering.
Authors: Mahajan VS, Demissie E, Alsufyani F, Kumari S, Yuen GJ, Viswanadham V, Huang A, Tran JQ, Moon JJ, Irvine DJ, Pillai S.
J Immunol
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